
EAST - AFNET 4:
Early treatment of atrial fibrillation for stroke prevention trial
This trial is partially supported by the German Center for Cardiovascular Research (Deutschen Zentrum für Herz-Kreislauf-Forschung e.V., DZHK) .
PATIENTS
End of patient enrollment 31.12.2016
End of follow-up 06.03.2020
2.789 Patienten randomised
135 recruting sites
Status June 2020
2745
Planned number of patients
PARTICIPATING COUNTRIES
11 European countries:
Belgium, Czech Republic, Denmark, France, Germany, Great Britain, Italy, Netherlands, Poland, Spain, Switzerland
PUBLICATIONS
Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck K-H, Mont L, Ng GA, Rekosz J, Schön N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G, for the EAST–AFNET 4 trial investigators. Early rhythm control therapy in patients with atrial fibrillation. New England Journal of Medicine. Epub 29 Aug 2020.
doi: (Link ist extern)10.1056/NEJMoa2019422
Haegeli L, Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J. 2015 Feb 1;36(5):255-6. doi: 10.1093/eurheartj/ehu476. Epub 2015 Jan 30.
Kirchhof P, Breithardt G, Camm AJ, Crijns H, Kuck K-H, Vardas P, Wegscheider K. Improving outcomes in patients with atrial fibrillation: Rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J 2013; 166(3):442-8. doi:10.1016/j.ahj.2013.05.015
Van Gelder IC, Haegeli LM, Brandes A, Heidbuchel H, Aliot E, Kautzner J, Szumowski L, Mont L, Morgan J, Willems S, Themistoclakis S, Gulizia M, Elvan A, Smit MD, Kirchhof P. Rationale and current perspective for early rhythm control therapy in atrial fibrillation. Europace 2011;13:1517-25. DOI:10.1093/europace/eur192.
Sponsor
Kompetenznetz Vorhofflimmern e.V., Münster, Germany
Coordinating Investigators
Prof. Paulus Kirchhof, Hamburg
Prof. Günter Breithardt, Münster
Prof. Harry Crijns, Maastricht
Prof. John Camm, London
Registration
ClinicalTrials.gov: NCT01288352
ISRCTN: ISRCTN04708680
EudraCT: 2010-021258-20
Website: www.easttrial.org