EAST - AFNET 4

EAST - AFNET 4:

Early treatment of atrial fibrillation for stroke prevention trial
 

This trial is partially supported by the German Center for Cardiovascular Research (Deutschen Zentrum für Herz-Kreislauf-Forschung e.V., DZHK) .

 

 

PATIENTS

End of patient enrollment 31.12.2016

End of follow-up 06.03.2020
 

2.789 Patienten randomised
135 recruting sites


Status June 2020

 

 

2745

Planned number of patients

 

PARTICIPATING COUNTRIES

 

11 European countries:

Belgium, Czech Republic, Denmark, France, Germany, Great Britain, Italy, Netherlands, Poland, Spain, Switzerland

 

PUBLICATIONS

Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck K-H, Mont L, Ng GA, Rekosz J, Schön N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G, for the EAST–AFNET 4 trial investigators. Early rhythm control therapy in patients with atrial fibrillation. New England Journal of Medicine. Epub 29 Aug 2020.
doi: (Link ist extern)10.1056/NEJMoa2019422

 

Haegeli L, Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J. 2015 Feb 1;36(5):255-6. doi: 10.1093/eurheartj/ehu476. Epub 2015 Jan 30.

 

Kirchhof P, Breithardt G, Camm AJ, Crijns H, Kuck K-H, Vardas P, Wegscheider K. Improving outcomes in patients with atrial fibrillation: Rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J 2013; 166(3):442-8. doi:10.1016/j.ahj.2013.05.015

 

Van Gelder IC, Haegeli LM, Brandes A, Heidbuchel H, Aliot E, Kautzner J, Szumowski L, Mont L, Morgan J, Willems S, Themistoclakis S, Gulizia M, Elvan A, Smit MD, Kirchhof P. Rationale and current perspective for early rhythm control therapy in atrial fibrillation. Europace 2011;13:1517-25. DOI:10.1093/europace/eur192.

Sponsor

Kompetenznetz Vorhofflimmern e.V., Münster, Germany

 

Coordinating Investigators

Prof. Paulus Kirchhof, Hamburg
Prof. Günter Breithardt, Münster
Prof. Harry Crijns, Maastricht
Prof. John Camm, London

Registration

ClinicalTrials.gov:  NCT01288352
 

ISRCTN:  ISRCTN04708680

EudraCT: 2010-021258-20

Website: www.easttrial.org