EAST - AFNET 4

EAST:

Early treatment of atrial fibrillation for stroke prevention trial (EAST)

Frühe Behandlung von Vorhofflimmern zur Verhinderung von Schlaganfällen

 

 

PATIENTEN

Ende Patienteneinschluss 31.12.2016

Ende Follow-Up 06.03.2020
 

2.789 Patienten randomisiert
135 rekrutierende Zentren


Stand Juni 2020

 

 

2745

Geplante Patientenzahl

 

BETEILIGTE LÄNDER

 

11 europäische Staaten:

Belgien, Dänemark, Deutschland, Frankreich, Großbritannien, Italien, Niederlande, Polen, Tschechien, Schweiz, Spanien

 

PUBLIKATIONEN

Jensen M, Suling A, Metzner A, Schnabel R, Borof K, Goette A, Haeusler KG, Zapf A, Wegscheider K, Fabritz L, Diener H-C, Thomalla G, Kirchhof P. Early rhythm-control therapy for atrial fibrillation in patients with a history of stroke: a subgroup analysis of the EAST- AFNET 4 trial. Lancet Neurol 2023; 22: 45–54. DOI: 10.1016/PIIS1474-4422(22)00436-7

Eckardt L, Sehner S, Suling A, Borof K, Breithardt G, Crijns HJGM, Goette A, Wegscheider K, Zapf A, Metzner A, Kirchhof P. Attaining sinus rhythm mediates improved outcome with early rhythm control therapy of atrial fibrillation: the EAST – AFNET 4 trial. European Heart Journal, 29 August 2022. doi: 10.1093/eurheartj/ehac471

Rillig A, Borof K, Breithardt G, Camm AJ, Crijns HJGM, Goette A, Kuck KH, Metzner A, Vardas P, Vettorazzi E, Wegscheider K, Zapf A, Kirchhof P. Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden. Circulation 2022. Epub 15 August 2022. . doi: (Link ist extern)10.1161/CIRCULATIONAHA.122.060274

Goette A, Borof K, Breithardt G, Camm AJ, Crijns HJG, Kuck KH, Wegscheider K, Kirchhof P. Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy. J Am Coll Cardiol. 2022;80(4):283-295 

Metzner A, Suling A, Brandes A,  Breithardt G, Camm AJ, Crijns HJGM, Eckardt L, Elvan A, Goette A, Haegeli L, Heidbuchel H, Kautzner J, Kuck KH, Mont L, NG A, Szumowski L, Themistoclakis S, van Gelder I, Vardas P, Wegscheider K, Willems S, Kirchhof P. Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial. Europace (2021) 00, 1–13, 02 September 2021. doi:10.1093/europace/euab200

Willems S, Borof K, Brandes A, Breithardt G, Camm AJ, Crijns HJGM, Eckardt L, Gessler N, Goette A, Haegeli L, Heidbuchel H, Kautzner J, NG A, Schnabel R, Suling A,  Szumowski L, Themistoclakis S, Vardas P, van Gelder I, Wegscheider K, Kirchhof P. Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial. European Heart Journal, 27 August 2021. doi:10.1093/eurheartj/ehab593

(Link ist extern)

Rillig A, Magnussen C, Ozga AK, Suling A, Brandes A, Breithardt G, Camm AJ, Crijns HJGM, Eckardt L, Elvan A, Goette A, Gulizia M, Haegeli L, Heidbuchel H, Kuck KH, NG A, Szumowski L, van Gelder I, Wegscheider K, Kirchhof P. Early rhythm control therapy in patients with atrial fibrillation and heart failure. Circulation 2021. Epub 30 July 2021. [published online ahead of print]. doi: (Link ist extern)10.1161/CIRCULATIONAHA.121.056323

McNamara DA, Chopra R, Ganantra RB, Suzuki T, Kirchhof P, Wegscheider K, Breithardt G. Letter to the editor: EAST-AFNET 4 Early rhythm control therapy in patients with atrial fibrillation. New England Journal of Medicine. Epub 04 February 2021. doi: 10:1056/NEJMc2032433

Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck K-H, Mont L, Ng GA, Rekosz J, Schön N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G, for the EAST–AFNET 4 trial investigators. Early rhythm control therapy in patients with atrial fibrillation. New England Journal of Medicine. Epub 29 Aug 2020.
doi: (Link ist extern)10.1056/NEJMoa2019422

Haegeli L, Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J. 2015 Feb 1;36(5):255-6. doi: 10.1093/eurheartj/ehu476. Epub 2015 Jan 30.

Kirchhof P, Breithardt G, Camm AJ, Crijns H, Kuck K-H, Vardas P, Wegscheider K. Improving outcomes in patients with atrial fibrillation: Rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J 2013; 166(3):442-8. doi:10.1016/j.ahj.2013.05.015

Van Gelder IC, Haegeli LM, Brandes A, Heidbuchel H, Aliot E, Kautzner J, Szumowski L, Mont L, Morgan J, Willems S, Themistoclakis S, Gulizia M, Elvan A, Smit MD, Kirchhof P. Rationale and current perspective for early rhythm control therapy in atrial fibrillation. Europace 2011;13:1517-25. DOI:10.1093/europace/eur192.

Gesamtverantwortung

Kompetenznetz Vorhofflimmern e.V. (AFNET), Münster

Wissenschaftliche Leitung

Prof. Paulus Kirchhof, Hamburg
Prof. Günter Breithardt, Münster
Prof. Harry Crijns, Maastricht
Prof. John Camm, London

Registrierung

ClinicalTrials.gov:  NCT01288352
 

ISRCTN:  ISRCTN04708680

EudraCT: 2010-021258-20

Website: http://www.easttrial.org