Molekulare Signaltransduktion in Vorhofmyozyten

Titel

Molekulare Signaltransduktion in Vorhofmyozyten sowie deren Wechselwirkung mit der Interzellularsubstanz bei Vorhofflimmern

Wissenschaftliche Leitung

Prof. Andreas Goette, Paderborn / Magdeburg

Gesamtverantwortung

Kompetenznetz Vorhofflimmern

Aktueller Stand

abgeschlossen

Finanzierung:

Bundesministerium für Bildung und Forschung (BMBF)

Publikationen

Goette A*, Bukowska A*, Dobrev D*, Pfeiffenberger J, Morawietz H, Strugala D, Wiswedel I, Röhl FW, Bergmann S, Bramlage P, Ravens U, Lendeckel U. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J, 05.03.2009; *shared first authorship

Bukowska A, Lendeckel U, Krohn A, Keilhoff G, ten Have S, Neumann KH, Goette A. Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney. Europace. 2008;10:1212-7.

Goette A, D'Alessandro A, Bukowska A, Kropf S, Mewis C, Stellbrink C, Tebbenjohanns J, Weiss C, Lendeckel U. Rationale for and design of the CREATIVE-AF trial: randomized, double-blind, placebo-controlled, crossover study of the effect of irbesartan on oxidative stress and adhesion molecules in patients with persistent atrial fibrillation. Clin Drug Investig. 2008; 28:565-72.

Hammwöhner M, Smid J, Lendeckel U, Goette A. New drugs for atrial fibrillation. J Interv Card Electrophysiol. 2008; 23:15-21. Review.

Bukowska A, Schild L, Keilhoff G, Hirte D, Neumann M, Gardemann A, Neumann KH, Röhl FW, Huth C, Goette A, Lendeckel U. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia. Exp Biol Med (Maywood). 2008; 233:558-74.

Goette A, Lendeckel U. Electrophysiological effects of angiotensin II. Part I: signal transduction and basic electrophysiological mechanisms. Europace. 2008; 10:238-41. Review.

Goette A, Bukowska A, Lendeckel U, Erxleben M, Hammwöhner M, Strugala D, Pfeiffenberger J, Röhl FW, Huth C, Ebert MP, Klein HU, Röcken C. Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression. Circulation. 2008; 117(6):732-42.

Bukowska A, Lendeckel U, Hirte D, Wolke C, Striggow F, Röhnert P, Huth C,. Klein HU, Goette A. (2006) Activation of the Calcineurin Signaling Pathway Induces Atrial Hypertrophy During Atrial Fibrillation. J Cell Mol Life Sci; 63: 333-342.